For pharma & research

Objective digital endpoints.

Run decentralised trials on real-world measures of quality of life and disease progression. Improve compliance, capture richer longitudinal evidence, and cut the cost of site visits — using devices participants already own.

Discuss a study → Validation & methods
96%
of participant-days captured passively, reducing missing data
40+
validated digital measures, ready to use as exploratory endpoints
↓
fewer site visits — lower burden for participants and sites alike
The measures

A library of real-world signal.

Continuous, passively-collected measures across motor, sleep and physiology — the substrate for objective digital endpoints.

Gait — cadence
Steps per minute during ambulation, day over day.
Motor
Gait — stride
Stride length and variability as a marker of stability.
Motor
Rest tremor
Amplitude and duration of tremor at rest.
Motor
Action tremor
Tremor during voluntary movement.
Motor
Activity volume
Daily active minutes and movement intensity.
Motor
Turning
Turn speed and smoothness during daily movement.
Motor
Sleep duration
Total nightly sleep and consistency.
Sleep
Sleep efficiency
Proportion of time in bed actually asleep.
Sleep
Nocturnal movement
Restlessness and awakenings overnight.
Sleep
Rest rhythm
Regularity of rest–activity cycles.
Sleep
Resting heart rate
Daily resting HR and trend.
Physiology
Heart-rate variability
Autonomic regulation over time.
Physiology
HR response
Heart-rate response to activity and recovery.
Physiology
Q-index
Composite measure of quality-of-life trend.
Composite
Symptom stability
Day-to-day variability across motor domains.
Composite
Progression slope
Longitudinal direction of change over months.
Composite

Measure availability and endpoint qualification depend on study design and regulatory context. Koios Care is a wellness solution and is not a medical device.

Why it matters

Richer evidence, less burden.

Episodic clinic assessments miss the day-to-day reality of living with Parkinson’s. Continuous, passive capture turns months of real life into analysable signal.

  • ✓Better compliance — no tasks or diaries means fewer dropouts and less missing data.
  • ✓Real-world validity — measures reflect everyday function, not a single supervised test.
  • ✓Lower cost — fewer in-person site visits for participants and sponsors.
  • ✓Longitudinal depth — continuous data reveals slopes and patterns episodic visits cannot.

Design your next study around real life.

Tell us about your programme and we’ll map the measures that fit.

Discuss a study → See publications